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Epilepsy Behav. 2009 Aug;15(4):529-34. doi: 10.1016/j.yebeh.2009.06.011. Epub 2009 Jul 17.

Clinical use of an herbal-derived compound (Huperzine A) to treat putative complex partial seizures in a dog.

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Clinical Sciences Department, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.


A Bernese mountain dog was diagnosed with complex partial seizures that were supported by electroencephalographic findings. Clinical signs of the problem included "star gazing," fly snapping, licking, vacuous chewing, and ongoing anxiety. Treatment with Huperzine A, a compound isolated from Chinese club moss with NMDA receptor blocking activity, anticholinesterase activity, and anticonvulsant properties, produced useful suppression of the abnormal behavior for more than months. A relapse occurred when the dog was treated with tramadol for joint pain and the improvement that had been made was not recaptured with Huperzine A. At this stage, phenobarbital therapy was instituted and the dog improved greatly. The role of Huperzine A in controlling seizures is discussed.

[Indexed for MEDLINE]

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