Format

Send to

Choose Destination
See comment in PubMed Commons below
Brain Cogn. 2010 Feb;72(1):73-85. doi: 10.1016/j.bandc.2009.06.003. Epub 2009 Jul 17.

Investigations of HPA function and the enduring consequences of stressors in adolescence in animal models.

Author information

1
Department of Psychology and Centre for Neuroscience, Brock University, St. Catharines, ON, Canada. cmccormick@brocku.ca

Abstract

Developmental differences in hypothalamic-pituitary-adrenal (HPA) axis responsiveness to stressors and ongoing development of glucocorticoid-sensitive brain regions in adolescence suggest that similar to the neonatal period of ontogeny, adolescence may also be a sensitive period for programming effects of stressors on the central nervous system. Although research on this period of life is scarce compared to early life and adulthood, the available research indicates that effects of stress exposure during adolescence differ from, and may be longer-lasting than, effects of the same stress exposure in adulthood. Research progress in animal models in this field is reviewed including HPA function and the enduring effects of stress exposures in adolescence on sensitivity to drugs of abuse, learning and memory, and emotional behaviour in adulthood. The effects of adolescent stress depend on a number of factors, including the age, gender, the duration of stress exposure, the type of stressor, and the time between stress exposure and testing.

PMID:
19616355
DOI:
10.1016/j.bandc.2009.06.003
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center