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Behav Brain Res. 2009 Dec 14;205(1):319-21. doi: 10.1016/j.bbr.2009.07.008. Epub 2009 Jul 16.

Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood.

Author information

1
Department of Psychiatry, University College Cork, Cork, Ireland; Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. g.clarke@ucc.ie

Abstract

The rat maternal separation paradigm can be used to examine the biological consequences of early-life stress. Immunomodulatory polyunsaturated fatty acids (PUFAs) have recently attracted attention in the study of stress-related disorders. We established the plasma PUFA profile of maternally separated rodents compared to controls. Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders.

PMID:
19616034
DOI:
10.1016/j.bbr.2009.07.008
[Indexed for MEDLINE]

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