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Mol Oncol. 2009 Aug;3(4):297-307. doi: 10.1016/j.molonc.2009.06.004. Epub 2009 Jun 26.

Ras/MAPK signaling from endomembranes.

Author information

1
Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA.

Abstract

Signal transduction along the Ras/MAPK pathway has been generally thought to take place at the plasma membrane. It is now evident that the plasma membrane is not the only platform capable of Ras/MAPK signal induction. Fusion of Ras with green fluorescent protein and the development of genetically encoded fluorescent probes for Ras activation have revealed signaling events on a variety of intracellular membranes including endosomes, the Golgi apparatus and the endoplasmic reticulum. Thus, the Ras/MAPK pathway is spatially compartmentalized within cells and this may afford greater complexity of signal output.

PMID:
19615955
PMCID:
PMC3003591
DOI:
10.1016/j.molonc.2009.06.004
[Indexed for MEDLINE]
Free PMC Article

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