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Curr Opin Cell Biol. 2009 Oct;21(5):630-5. doi: 10.1016/j.ceb.2009.06.003. Epub 2009 Jul 15.

Stem cells, microenvironment mechanics, and growth factor activation.

Author information

1
Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Physicochemical features of a cell's microenvironment can exert important effects on cell behavior and include the effects of matrix elasticity on cell differentiation processes, but molecular mechanisms are largely mysterious. Here we highlight recent reports of a mechanical dependence to growth factor activation, with a particular focus on release of TGFbeta (Transforming Growth Factor beta) from its large latent complex via forced unfolding. We discuss these processes and pathways in the contexts of matrix adhesion and fluid shearing as they might relate to stem cell differentiation and other mechanisms in development, disease, and repair.

PMID:
19615877
PMCID:
PMC2775547
DOI:
10.1016/j.ceb.2009.06.003
[Indexed for MEDLINE]
Free PMC Article

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