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Microbes Infect. 2009 Oct;11(12):928-34. doi: 10.1016/j.micinf.2009.07.003. Epub 2009 Jul 15.

The role of autoimmune regulator (Aire) in the development of the immune system.

Author information

1
Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. mitsuru@ier.tokushima-u.ac.jp

Abstract

AIRE is the gene responsible for a rather rare hereditary type of autoimmune disease. The mechanism underlying the autoimmune pathogenesis caused by AIRE deficiency is a focus of intense research because it could provide clues to the fundamental question of how the immune system discriminates between self and non-self within the thymic microenvironment.

PMID:
19615461
DOI:
10.1016/j.micinf.2009.07.003
[Indexed for MEDLINE]

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