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Int J Hematol. 2009 Sep;90(2):212-216. doi: 10.1007/s12185-009-0383-5. Epub 2009 Jul 17.

Some patients with NHL possessed immunoreactivity to gliadin and to cow's milk proteins.

Author information

1
Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000, Belgrade, Serbia. juranicz@ncrc.ac.yu.
2
Institute of Oncology and Radiology of Serbia, Pasterova 14, 11000, Belgrade, Serbia.
3
Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
4
Faculty of Stomatology, University of Belgrade, Belgrade, Serbia.
5
Institute for Child and Youth Health Care of Vojvodina, 11000, Novi Sad, Serbia.

Abstract

Non-Hodgkin lymphoma (NHL) represents heterogeneous group of diseases either B, or T cell origin. In order to assess whether food antigens contribute to the imbalance of immune response, the aim of this work was screening the sera of patients with (mostly) B cell NHL, and of people with non-malignant health disorders (NMD), as well as of healthy people for their immunoreactivity to food constituent gliadin, and to cow's milk proteins. Data obtained by ELISA tests show the existence of the enhanced immunoreactivity to food antigens in some NHL patients, as well as in some people with NMD. The high degree of coincidence in the presence of enhanced levels of immune complexes in circulation (CIC) and of immunoreactivity with gliadin in immunofixation (after the serum protein electrophoresis in agarose gel in veronal buffer, at pH 8.6) especially in NHL patients points that some antigliadin immunoreactivity unrevealed in ELISA tests could be hidden in CIC. This, only in the presence of malignant genotype, as well as the enhanced levels of CIC in some of NHL patients could both, at least partially contribute to the persistent non-specific support of disease. They call for the new research of the clinical importance of both, the elevated humoral immunity to food antigens (gluten, cow's milk proteins) for the course of this very severe hematological disease.

PMID:
19609644
DOI:
10.1007/s12185-009-0383-5
[Indexed for MEDLINE]

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