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J Antibiot (Tokyo). 2009 Sep;62(9):501-5. doi: 10.1038/ja.2009.60. Epub 2009 Jul 17.

Bingchamides A and B, two novel cyclic pentapeptides from the Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties.

Author information

1
School of Life Science, Northeast Agricultural University, Harbin, China.

Abstract

Two novel cyclic pentapeptides, bingchamides A (1) and B (2), have been isolated from the organic extracts of the mycelium of Streptomyces bingchenggensis. The structures of 1 and 2 were elucidated on the basis of extensive 1D and 2D NMR, as well as HRESI-MS, electrospray ionization-MS, UV and IR spectroscopic data analysis. Bingchamides A (1) and B (2) exhibited in vitro cytotoxicity toward human colon carcinoma cell line HCT-116 with the IC(50) values of 14.1 and 18.0 microg ml(-1), respectively. The bingchamides A (1) and B (2) scaffolds are probably promising structures for the development of new antitumor agents.

PMID:
19609291
DOI:
10.1038/ja.2009.60
[Indexed for MEDLINE]

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