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Nat Rev Immunol. 2009 Aug;9(8):543-55. doi: 10.1038/nri2602. Epub 2009 Jul 17.

Mechanisms and functions for the duration of intercellular contacts made by lymphocytes.

Author information

1
Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College London, South Kensington, London, SW7 2AZ, UK. d.davis@imperial.ac.uk

Abstract

Communication across intercellular contacts is central to establishing appropriate innate and adaptive immune responses. Recent imaging of lymphocyte interactions suggests that a complex orchestration of cell-cell contact times is a key correlate to establishing appropriate immune responses. Here I review the molecular and cellular processes that influence the duration of intercellular contacts, including integrin activation and dynamic changes in membrane morphology. I discuss how these processes can be regulated, for example, by the balance of activating and inhibitory receptor signals, and how they can establish the appropriate outcome for individual cell-cell interactions.

PMID:
19609264
DOI:
10.1038/nri2602
[Indexed for MEDLINE]

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