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Am J Respir Crit Care Med. 2009 Oct 1;180(7):618-31. doi: 10.1164/rccm.200905-0722OC. Epub 2009 Jul 16.

Meta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20 years' research.

Author information

1
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Abstract

RATIONALE:

Chronic obstructive pulmonary disease (COPD) is a complex disorder with high mortality worldwide. Studies on the role of candidate genes and their polymorphisms in COPD development have so far produced ambiguous results.

OBJECTIVES:

The aim of this study was to reveal the role of COPD candidate genes using data collected in previous research.

METHODS:

We performed meta-analyses on 20 polymorphisms in 12 genes, after searching the PubMed and Embase databases for publications on COPD. These genes involve three main pathways associated with COPD development: the inflammatory, protease-antiprotease balance, and antioxidant pathways.

MEASUREMENTS AND MAIN RESULTS:

We obtained significant results for three TGFB1 polymorphisms, although these were based only on a few studies. The IL1RN VNTR polymorphism increases the risk for COPD (odds ratio [OR], 1.7; 95% confidence interval [CI], 1.09-2.65), whereas the TNFA -308 G/A polymorphism does so only in Asian populations (OR, 2.01; 95% CI, 1.21-3.31). The GSTP1 I105V polymorphism was protective for COPD in Asian populations only (OR, 0.69; 95% CI, 0.56-0.85).

CONCLUSIONS:

These results demonstrate the importance of ethnicity in identifying specific COPD genes.

PMID:
19608716
DOI:
10.1164/rccm.200905-0722OC
[Indexed for MEDLINE]

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