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Bioorg Med Chem Lett. 2009 Aug 15;19(16):4698-701. doi: 10.1016/j.bmcl.2009.06.070. Epub 2009 Jun 21.

Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)).

Author information

1
School of Science, University of the West of Scotland, Paisley, PA1 2BE Scotland, UK. sabbir.ahmed@uws.ac.uk

Abstract

We report the synthesis and biochemical evaluation of a range of 4-sulfonated derivatives of 4-hydroxybenzyl imidazole which has been targetted against the two components of 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)), namely, 17alpha-hydroxylase (17alpha-OHase) and 17,20-lyase (lyase). The results from the biochemical testing suggest that the compounds synthesised are highly potent inhibitors possessing excellent selectivity towards the lyase component.

PMID:
19608417
DOI:
10.1016/j.bmcl.2009.06.070
[Indexed for MEDLINE]

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