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Fertil Steril. 2009 Sep;92(3):1169.e9-1169.e10. doi: 10.1016/j.fertnstert.2009.06.007. Epub 2009 Jul 15.

Normal pregnancy after tetraploid karyotype on trophectoderm biopsy.

Author information

1
Division of Reproductive Endocrinology and Infertility, Stanford Hospital and Clinics, Palo Alto, California, USA.

Abstract

OBJECTIVE:

To report a case of successful pregnancy after trophectoderm biopsy and fluorescence in situ hybridization (FISH) revealed a tetraploid karyotype.

DESIGN:

Case report.

SETTING:

A university medical center.

PATIENT(S):

An infertility patient desiring trophectoderm biopsy on frozen blastocysts to facilitate preimplantation genetic screening.

INTERVENTION(S):

Frozen blastocysts were thawed on the evening before transfer. Trophectoderm biopsy was performed the following morning. FISH results were available the same day, and two embryos with tetraploid results were transferred.

MAIN OUTCOME MEASURE(S):

Chorionic villus sample (CVS) and newborn exam.

RESULT(S):

Normal diploid CVS result and a healthy male infant.

CONCLUSION(S):

Although multiple cells can be analyzed using trophectoderm biopsy, abnormalities in the trophectoderm may not be present in the inner cell mass.

[Indexed for MEDLINE]

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