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J Mol Cell Cardiol. 2010 Jan;48(1):71-5. doi: 10.1016/j.yjmcc.2009.07.002. Epub 2009 Jul 14.

Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale!

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1
Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

Abstract

Reconstitution of K(ATP) channel activity from coexpression of members of the pore-forming inward rectifier gene family (Kir6.1, KCNJ8, and Kir6.2 KCNJ11) with sulfonylurea receptors (SUR1, ABCC8, and SUR2, ABCC9) of the ABCC protein sub-family, has led to the elucidation of many details of channel gating and pore properties, as well as the essential roles of Kir6.2 and SUR2 subunits in generating cardiac ventricular K(ATP). However, despite this extensive body of knowledge, there remain significant holes in our understanding of the physiological role of the cardiac K(ATP) channel, and surprising new findings keep emerging. Recent findings from genetically modified animals include the apparent insensitivity of cardiac sarcolemmal channels to nucleotide levels, and unenvisioned complexities of the subunit make-up of the cardiac channels. This topical review focuses on these new findings and considers their implications.

PMID:
19607836
PMCID:
PMC2813340
DOI:
10.1016/j.yjmcc.2009.07.002
[Indexed for MEDLINE]
Free PMC Article
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