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Neuron. 2009 Jul 16;63(1):6-8. doi: 10.1016/j.neuron.2009.07.001.

It's lonely at the top: winning climbing fibers ascend dendrites solo.

Author information

  • 1Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.

Abstract

In mammals, climbing fiber axons compete for sole innervation at each Purkinje cell. At the same time, synapses disappear from Purkinje somata and appear in great numbers on the dendrites. In this issue of Neuron, Hashimoto et al. show that, by the time climbing fibers ascend the dendrites, the winner and losers are already decided.

PMID:
19607787
PMCID:
PMC2790139
DOI:
10.1016/j.neuron.2009.07.001
[PubMed - indexed for MEDLINE]
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