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Expert Opin Pharmacother. 2009 Aug;10(12):1979-94. doi: 10.1517/14656560903120899.

Single-pill combination of amlodipine and valsartan in the management of hypertension.

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  • 1Department of Internal Medicine, Wayne State University School of Medicine, 4201 St. Antoine, Suite 2E, Detroit, MI 48201, USA. jflack@med.wayne.edu

Abstract

Combination therapy is increasingly recommended for selected patients with hypertension to facilitate prompt attainment and maintenance of goal blood pressure (BP). Single-pill combination therapy simplifies treatment and optimizes long-term compliance. Amlodipine, a dihydropyridine calcium antagonist, and valsartan, an angiotensin receptor blocker, are well-established antihypertensive agents with complementary mechanisms of action. This combination lowers BP significantly more than either of its components, and valsartan reduces the incidence of dose-related amlodipine-induced edema. Rigorous clinical trial data have proven the BP-lowering efficacy and high tolerability of the amlodipine/valsartan combination in patients with moderate to severe hypertension as well as other difficult-to-treat populations. Amlodipine/valsartan is indicated as initial therapy in patients who are unlikely to be controlled with a single drug and as second-line therapy in patients not responding adequately to monotherapy.

PMID:
19606937
DOI:
10.1517/14656560903120899
[PubMed - indexed for MEDLINE]
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