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Clin Pharmacol Ther. 2009 Oct;86(4):383-6. doi: 10.1038/clpt.2009.127. Epub 2009 Jul 15.

Macrolide-induced digoxin toxicity: a population-based study.

Author information

1
The Institute for Clinical Evaluative Sciences, Ontario, Canada.

Abstract

In this 15-year, population-based, nested case-control study, we investigated the association between hospitalization for digoxin toxicity and recent exposure to individual macrolide antibiotics. Clarithromycin was associated with the highest risk of digoxin toxicity (adjusted odds ratio (OR) 14.8; 95% confidence interval (CI) 7.9-27.9), whereas erythromycin and azithromycin were associated with much lower risk (adjusted OR 3.7; 95% CI 1.7-7.9; and adjusted OR 3.7; 95% CI 1.1-12.5, respectively). We found no increased risk with a neutral comparator, cefuroxime (adjusted OR 0.8; 95% CI 0.2-3.4).

PMID:
19606089
DOI:
10.1038/clpt.2009.127
[Indexed for MEDLINE]

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