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Neurosci Lett. 1976 Aug;2(6):301-5.

Neural agryrophilia induced by puromycin: A directed Golgi-like method.

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Department of Anatomy, University of Virginia, Charlottesville, Va. 22901 U.S.A.


Puromycin injected intracerebrally in rats renders affected neurons extremely argyrophilic, which makes it possible to demonstrate their fine geometry by the aid of a reduced silver impregnation procedure. The technique shows promise as a directed Golgi-like method. The abortive action of puromycin on protein synthesis produces a multitude of argyrophilic peptide fragments, which are subsequently transported throughout the neuron as protein-like moieties. It is hypothesized that these fragments serve as nucleation points for subsequent silver deposition.

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