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J Immunol Methods. 1991 Nov 5;144(1):63-7.

A new qualitative method for detecting IgD in unconcentrated cerebrospinal fluid.

Author information

1
Department of Special Chemical Pathology, National Hospital for Neurology and Neurosurgery, London, U.K.

Abstract

We report a method which is capable of demonstrating the isoelectric focusing (IEF) pattern of immunoglobulin D in unconcentrated cerebrospinal fluid (CSF) samples containing as little as 0.1-0.5 ng of total IgD. The method used was an immuno-sandwich technique, with alkaline phosphatase enzyme amplification. Oligoclonal and polyclonal IgD patterns were seen in CSF samples. No cross-reactivity with other immunoglobulins (IgG, IgA and IgM) was detected.

PMID:
1960408
[Indexed for MEDLINE]

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