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Pharmacogenomics. 2009 Jul;10(7):1067-76. doi: 10.2217/pgs.09.56.

Epigenetic and microRNA-dependent control of cytochrome P450 expression: a gap between DNA and protein.

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Section of Pharmacogenetics, Department of Physiology & Pharmacology, Karolinska Institutet, Sweden.


Although pharmacogenetics has been instrumental in describing interindividual variations in drug metabolism, epigenetic factors offer another blanket of information that could give a more vivid picture and help in developing a more personalized therapy. The dynamic aspect of epigenetics could likewise provide more definite answers to the role of changing environmental factors in drug response: the bridge that connects the environment to the genome. In this review we discuss known epigenetic and microRNA-dependent regulation of the human drug-metabolizing cytochromes P450 to help explain the unknown factors of variable drug response.

[Indexed for MEDLINE]

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