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J Proteome Res. 2009 Sep;8(9):4328-32. doi: 10.1021/pr900349r.

Reanalysis of Tyrannosaurus rex Mass Spectra.

Author information

1
Palo Alto Research Center, Palo Alto, CA 94304, USA. bern@parc.com

Abstract

Asara et al. reported the detection of collagen peptides in a 68-million-year-old Tyrannosaurus rex bone by shotgun proteomics. This finding has been called into question as a possible statistical artifact. We reanalyze Asara et al.'s tandem mass spectra using a different search engine and different statistical tools. Our reanalysis shows a sample containing common laboratory contaminants, soil bacteria, and bird-like hemoglobin and collagen.

PMID:
19603827
PMCID:
PMC2738754
DOI:
10.1021/pr900349r
[Indexed for MEDLINE]
Free PMC Article

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