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IUBMB Life. 2009 Sep;61(9):880-94. doi: 10.1002/iub.230.

Mammalian polyamine metabolism and function.

Author information

1
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. aep1@psu.edu

Abstract

Polyamines are ubiquitous small basic molecules that play multiple essential roles in mammalian physiology. Their cellular content is highly regulated and there is convincing evidence that altered metabolism is involvement in many disease states. Drugs altering polyamine levels may therefore have a variety of important targets. This review will summarize the current state of understanding of polyamine metabolism and function, the regulation of polyamine content, and heritable pathological conditions that may be derived from altered polyamine metabolism.

PMID:
19603518
PMCID:
PMC2753421
DOI:
10.1002/iub.230
[Indexed for MEDLINE]
Free PMC Article

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