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J Cell Mol Med. 2009 Sep;13(9A):2800-21. doi: 10.1111/j.1582-4934.2009.00845.x. Epub 2009 Jul 7.

Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy.

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  • 1Centre for Liver Disease, School of Medicine and Medical Science, Mater Misericordiae University Hospital, University College Dublin, Dublin, Ireland.

Abstract

Reactive oxygen species (ROS) form as a natural by-product of the normal metabolism of oxygen and play important roles within the cell. Under normal circumstances the cell is able to maintain an adequate homeostasis between the formation of ROS and its removal through particular enzymatic pathways or via antioxidants. If however, this balance is disturbed a situation called oxidative stress occurs. Critically, oxidative stress plays important roles in the pathogenesis of many diseases, including cancer. Epigenetics is a process where gene expression is regulated by heritable mechanisms that do not cause any direct changes to the DNA sequence itself, and disruption of epigenetic mechanisms has important implications in disease. Evidence is emerging that histone deacetylases (HDACs) play decisive roles in regulating important cellular oxidative stress pathways including those involved with sensing oxidative stress and those involved with regulating the cellular response to oxidative stress. In particular aberrant regulation of these pathways by HDACs may play critical roles in cancer progression. In this review we discuss the current evidence linking epigenetics and oxidative stress and cancer, using chronic obstructive pulmonary disease and non-small cell lung cancer to illustrate the importance of epigenetics on these pathways within these disease settings.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00006019 NCT00671151 NCT00387465 NCT00003684 NCT00073385 NCT00119496 NCT00084981 NCT00662311 NCT00667082 NCT00041158 NCT00735826 NCT00634413 NCT00299858 NCT00241631 NCT00893009 NCT00481078 NCT00019825 NCT00020579 NCT00738751 NCT00702572.

PMID:
19602054
PMCID:
PMC4498937
DOI:
10.1111/j.1582-4934.2009.00845.x
[PubMed - indexed for MEDLINE]
Free PMC Article
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