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Nat Methods. 2009 Aug;6(8):589-92. doi: 10.1038/nmeth.1348. Epub 2009 Jul 13.

Metabolic network analysis integrated with transcript verification for sequenced genomes.

Author information

1
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.

Abstract

With sequencing of thousands of organisms completed or in progress, there is a growing need to integrate gene prediction with metabolic network analysis. Using Chlamydomonas reinhardtii as a model, we describe a systems-level methodology bridging metabolic network reconstruction with experimental verification of enzyme encoding open reading frames. Our quantitative and predictive metabolic model and its associated cloned open reading frames provide useful resources for metabolic engineering.

PMID:
19597503
PMCID:
PMC3139173
DOI:
10.1038/nmeth.1348
[Indexed for MEDLINE]
Free PMC Article

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