Format

Send to

Choose Destination
Nat Genet. 2009 Aug;41(8):876-8. doi: 10.1038/ng.417. Epub 2009 Jul 13.

A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.

Author information

1
DeCode Genetics, Reykjavik, Iceland. daniel.gudbjartsson@decode.is

Abstract

We expanded our genome-wide association study on atrial fibrillation (AF) in Iceland, which previously identified risk variants on 4q25, and tested the most significant associations in samples from Iceland, Norway and the United States. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10)). This variant also associated with ischemic stroke (OR = 1.11, P = 0.00054) and cardioembolic stroke (OR = 1.22, P = 0.00021) in a combined analysis of five stroke samples.

PMID:
19597491
PMCID:
PMC2740741
DOI:
10.1038/ng.417
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center