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FEBS Lett. 1991 Nov 18;293(1-2):164-8.

Bacterioferritins and ferritins are distantly related in evolution. Conservation of ferroxidase-centre residues.

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Krebs Institute for Biomolecular Research, University of Sheffield, Western Bank, UK.


Iron-storage proteins can be divided into two classes; the bacterioferritins and ferritins. In spite of many apparent structural and functional analogies, no significant amino acid sequence similarity has been detected previously. This report now reveals a distant evolutionary relationship between bacterioferritins and ferritins derived by 'Profile Analysis'. Optimum alignment of bacterioferritin and ferritin sequences suggests that key residues of the ferroxidase centres of ferritins are conserved in bacterioferritins.

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