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Cell. 2009 Jul 10;138(1):16-8. doi: 10.1016/j.cell.2009.06.024.

Disorder, promiscuity, and toxic partnerships.

Author information

1
Department of Chemistry and Biochemistry, University of Texas at Austin, 2500 Speedway, Austin, TX 78712-1064, USA. marcotte@icmb.utexas.edu

Abstract

Many genes are toxic when overexpressed, but general mechanisms for this toxicity have proven elusive. Vavouri et al. (2009) find that intrinsic protein disorder and promiscuous molecular interactions are strong determinants of dosage sensitivity, explaining in part the toxicity of dosage-sensitive oncogenes in mice and humans.

PMID:
19596229
PMCID:
PMC2848715
DOI:
10.1016/j.cell.2009.06.024
[Indexed for MEDLINE]
Free PMC Article

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