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Psychol Sci. 2009 Sep;20(9):1070-3. doi: 10.1111/j.1467-9280.2009.02398.x. Epub 2009 Jul 6.

Genes for psychosis and creativity: a promoter polymorphism of the neuregulin 1 gene is related to creativity in people with high intellectual achievement.

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1
Semmelweis University, Budapest H1083, Hungary. szkeri@phys.szote.u-szeged.hu

Abstract

Why are genetic polymorphisms related to severe mental disorders retained in the gene pool of a population? A possible answer is that these genetic variations may have a positive impact on psychological functions. Here, I show that a biologically relevant polymorphism of the promoter region of the neuregulin 1 gene (SNP8NRG243177/rs6994992) is associated with creativity in people with high intellectual and academic performance. Intriguingly, the highest creative achievements and creative-thinking scores were found in people who carried the T/T genotype, which was previously shown to be related to psychosis risk and altered prefrontal activation.

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