Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Pediatr Obes. 2010 Apr;5(2):157-60. doi: 10.3109/17477160903111789.

Human adenovirus-36 antibody status is associated with obesity in children.

Author information

1
Obetech Obesity Research Center, Richmond, VA 23219, USA. ratkinson2@vcu.edu

Abstract

BACKGROUND:

Human adenovirus-36 (Ad-36) is thought to induce obesity by a direct effect of the viral E4orf1 gene on lipogenic enzymes in host adipocytes. Ad-36 prevalence is 30% in obese adults, but prevalence has not been reported in childhood obesity.

OBJECTIVES:

To determine the prevalence of Ad-36 infection in obese Korean children (age 14.8 +/- 1.9; range 8.3-6.3 years); correlation of infection with BMI z-score and other obesity measures.

METHODS:

Blood was drawn at the annual school physical exam or clinic visit; Ad-36 status was determined by serum neutralization assay; and routine serum chemistry values.

RESULTS:

A total of 30% of subjects were positive (N = 25) for Ad-36; 70% were negative (N = 59). Significantly higher BMI z-scores (1.92 vs. 1.65, p < 0.01) and waist circumferences (96.3 vs. 90.7 cm, p = 0.05) were found in infected versus uninfected children. Cardiovascular risk factors were not significantly different.

CONCLUSIONS:

Ad-36 infection is common in obese Korean children and correlates highly with obesity. Ad-36 may have played a role in the obesity and Type 2 diabetes epidemic in children.

PMID:
19593728
DOI:
10.3109/17477160903111789
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center