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J Bacteriol. 2009 Sep;191(18):5628-33. doi: 10.1128/JB.00510-09. Epub 2009 Jul 10.

The Mycobacterium tuberculosis sigma factor sigmaB is required for full response to cell envelope stress and hypoxia in vitro, but it is dispensable for in vivo growth.

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1
PHRI Center of NJMS-UMDNJ, 225 Warren Street, Newark, New Jersey 07103-3535, USA.

Abstract

The numerous sigma (sigma) factors present in Mycobacterium tuberculosis are indicative of the adaptability of this pathogen to different environmental conditions. In this report, we describe the M. tuberculosis sigma(B) regulon and the phenotypes of an M. tuberculosis sigB mutant strain exposed to cell envelope stress, oxidative stress, and hypoxia. The sigB mutant was especially defective in survival under hypoxic conditions in vitro, but it was not attenuated for growth in THP-1 cells or during mouse and guinea pig infection.

PMID:
19592585
PMCID:
PMC2737972
DOI:
10.1128/JB.00510-09
[Indexed for MEDLINE]
Free PMC Article
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