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Bioorg Med Chem Lett. 2009 Aug 15;19(16):4794-8. doi: 10.1016/j.bmcl.2009.06.042. Epub 2009 Jun 14.

7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists.

Author information

1
Global Discovery Chemistry, Novartis Institutes of Biomedical Research, Horsham Research Centre, Horsham, West Sussex RH12 5AB, United Kingdom. david.sandham@novartis.com

Abstract

High throughput screening identified a 7-azaindole-3-acetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a highly selective compound with good functional potency for inhibition of human eosinophil shape change in whole blood and oral bioavailability in the rat.

PMID:
19592244
DOI:
10.1016/j.bmcl.2009.06.042
[Indexed for MEDLINE]

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