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Cell Mol Life Sci. 2009 Oct;66(20):3277-88. doi: 10.1007/s00018-009-0085-4. Epub 2009 Jul 10.

Polyunsaturated fatty acids and cardiovascular disease.

Author information

1
Laboratory of Micronutrients and Cardiovascular Disease, Université Pierre et Marie Curie, Paris, France. doriane.richard@snv.jussieu.fr

Abstract

Replacing saturated with polyunsaturated (PUFAs) rather than monounsaturated fatty acids or carbohydrates results in cardiovascular prevention over a wide range of intakes. The mechanisms by which PUFAs reduce cardiovascular risk are manifold, and the extent and precise nature of their activities is the subject of several investigations, spanning from in vitro mechanistic studies to human intervention trials. This article reviews the most up-to-date evidence of the association between PUFA consumption and reduced cardiovascular mortality.

PMID:
19590823
DOI:
10.1007/s00018-009-0085-4
[Indexed for MEDLINE]

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