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J Clin Biochem Nutr. 2009 Jul;45(1):101-9. doi: 10.3164/jcbn.08-263. Epub 2009 Jun 30.

Effects of the Cellcultured Acanthopanax senticosus Extract on Antioxidative Defense System and Membrane Fluidity in the Liver of Type 2 Diabetes Mouse.

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1
The Center for Traditional Microorganism Resources, Keimyung University, 1000 Shndang-Dong, Dalseo-Gu, Daegu 704-701, Korea.

Abstract

This study examined the effect of cellcultured Acanthopanax senticosus (A. senticosus) extract on the antioxidative defense system, oxidative stress and cell membrane fluidity in the liver of type 2 diabetes in the C57BL/6J mouse as an animal which is genetically prone to develop insulin resistance and obesity/diabetes. C57BL/6J mice were randomly divided, control diet (N-C), high fat diet (DM-C), control diet plus A. senticosus extract (N-CASM), and high fat diet plus A. senticosus extract (DM-CASM). The mice were orally administered an A. senticosus extract (0.5 g/kg body weight) in the N-CASM and DM-CASM groups once a day for 12 weeks, and distilled water in the N-C and DM-C groups. Cellcultured A. senticosus extract was found to be excellent for strengthening the antioxidative defense system, reducing the generation of reactive oxygen species (ROS) and damaging oxidative substances, and maintaing membrane fluidity (MF) in the liver of type 2 diabetes mouse.

KEYWORDS:

C57BL/6J mice; Cellcultured Acanthopanax senticosus extract; antioxidative defense system; membrane fluidity; oxidative stress

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