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Nat Biotechnol. 2009 Aug;27(8):743-5. doi: 10.1038/nbt.1554. Epub 2009 Jul 9.

Variation in the safety of induced pluripotent stem cell lines.

Author information

1
Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.

Abstract

We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. Teratoma-formation of SNS from embryonic fibroblast-derived iPS cells was similar to that of SNS from embryonic stem (ES) cells. In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells.

PMID:
19590502
DOI:
10.1038/nbt.1554
[Indexed for MEDLINE]

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