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J Clin Rheumatol. 2009 Aug;15(5):247-9. doi: 10.1097/RHU.0b013e3181b0fca6.

Unilateral eosinophilic fasciitis: an under-recognized subtype?

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1
Medical University of South Carolina, Division of Rheumatology, Charleston, SC, USA. danielro@musc.edu

Abstract

Symmetric skin thickening of the limbs with deep fascial inflammation is the hallmark of eosinophilic fasciitis. We describe a woman who presented with unilateral progressive skin thickening. Examination of a full thickness skin biopsy revealed an inflammatory process and fascial changes consistent with eosinophilic fasciitis. In contrast to other scleroderma mimics, eosinophilic fasciitis generally responds rapidly to glucocorticoid therapy. It is possible that unilateral eosinophilic fasciitis is under-recognized and can easily be misdiagnosed as another scleroderma variant if a full thickness biopsy is not reviewed by a dermatopathologist. Recognition of this subtype of eosinophilic fasciitis is important given the profound differences in prognosis of eosinophilic fasciitis and other scleroderma variants.

PMID:
19590443
DOI:
10.1097/RHU.0b013e3181b0fca6
[Indexed for MEDLINE]
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