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Dermatology. 2009;219(2):143-7. doi: 10.1159/000228337. Epub 2009 Jul 8.

The effect of combined treatment with oral clindamycin and oral rifampicin in patients with hidradenitis suppurativa.

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1
Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands. h.vanderzee@erasmusmc.nl

Abstract

BACKGROUND:

A previous limited study showed promising results of combined oral treatment with rifampicin 600 mg and clindamycin 600 mg for 10 weeks.

OBJECTIVE:

To expand and to validate the basis for this therapy, we reviewed the response to different treatment durations.

METHOD:

A retrospective study in 34 patients.

RESULTS:

Twenty-eight of 34 patients (82%) experienced at least partial improvement, and 16 (47%) showed a total remission. The maximum effect of treatment appeared within 10 weeks. Following total remission, 8 of 13 (61.5%) patients treated as mentioned above experienced a relapse after a mean period of 5.0 months. Nonresponders were predominantly patients with severe disease.

CONCLUSION:

Combination treatment with oral rifampicin and clindamycin is a promising treatment option for hidradenitis suppurativa, despite the frequent occurrence of diarrhea as a side effect. The length and the dosage of treatment are not yet firmly established.

PMID:
19590174
DOI:
10.1159/000228337
[Indexed for MEDLINE]
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