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Curr Opin Pharmacol. 2009 Aug;9(4):411-8. doi: 10.1016/j.coph.2009.06.011. Epub 2009 Jul 7.

Inflammation and pancreatic cancer: an evidence-based review.

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  • 1University of Pittsburgh School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Medical Arts Building, 4th floor, Office 400.5, 3708 5th Ave., Pittsburgh, PA 15213, United States.


There is a growing awareness that inflammation plays a contributory role in numerous pathologies, including pancreatic carcinogenesis. Inflammatory states are characterized by the creation of reactive oxygen species and the induction of cell cycling for tissue growth and repair. The initiation, promotion and expansion of tumors may be influenced by numerous components that function in the inflammatory response. Recognized risk factors for pancreatic cancer include cigarette smoking, chronic/hereditary pancreatitis, obesity and type II diabetes. Each risk factor is linked by the fact that the inflammatory state significantly drives its pathology. This article will outline how inflammatory mechanisms are etiologically linked to pancreatic adenocarcinoma.

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