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Fertil Steril. 2010 Jul;94(2):496-501. doi: 10.1016/j.fertnstert.2009.03.040. Epub 2009 Jul 8.

In vitro maturation for patients with repeated in vitro fertilization failure due to "oocyte maturation abnormalities".

Author information

1
IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Israel. ariel.hourvitz@sheba.health.gov.il

Abstract

OBJECTIVE:

To investigate the efficacy of in vitro oocyte maturation (IVM) in women with repeated failure of IVF treatments due to follicular developmental abnormalities.

DESIGN:

Prospective longitudinal study.

SETTING:

The IVF unit of a university-affiliated medical center.

PATIENT(S):

Seven women with three or more IVF failures due to abnormal oocyte development resulting in no egg retrieval (empty follicle syndrome [EFS]), oocyte maturation arrest, or failure of fertilization.

INTERVENTION(S):

Immature oocyte collection, with or without minimal ovarian stimulation, IVM of the oocytes, insemination by intracytoplasmic sperm injection (ICSI), and embryo transfer.

MAIN OUTCOME MEASURE(S):

Number of aspirated oocytes, maturation, fertilization and cleavage rates, pregnancy, and ongoing pregnancy.

RESULT(S):

Seven women underwent seven IVM cycles. Four of them received a minimal stimulation of 75 IU FSH for 3-4 days. Oocytes were retrieved from all subjects (mean 7.1 +/- 3.3 oocytes/cycle). The in vitro maturation rate was 39.6% (mean 2.7 +/- 2.9 matured oocytes available for fertilization in four patients). The mean fertilization rate was 45.8% +/- 31.6%. Four women had embryo transfer. Two patients with previous genuine EFS conceived and delivered.

CONCLUSION(S):

IVM should be considered for women with previous genuine EFS. The role of IVM in other indications of oocyte maturation deficits warrants further investigation.

[Indexed for MEDLINE]

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