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Fertil Steril. 2010 Sep;94(4):1314-9. doi: 10.1016/j.fertnstert.2009.05.019. Epub 2009 Jul 8.

Replete vitamin D stores predict reproductive success following in vitro fertilization.

Author information

1
Kocaeli University, School of Medicine, Department of Obstetrics and Gynecology, Kocaeli, Turkey.

Abstract

OBJECTIVE:

To determine whether 25OH-D levels in the follicular fluid (FF) of infertile women undergoing IVF demonstrate a relationship with IVF cycle parameters and outcome, hypothesizing that levels of 25OH-D in body fluids are reflective of vitamin repletion status.

DESIGN:

Prospective cohort study.

SETTING:

Academic tertiary care center.

PATIENT(S):

Eighty-four infertile women undergoing IVF.

INTERVENTION(S):

Follicular fluid from follicles>or=14 mm; serum (n = 10) and FF levels of 25OH-D.

MAIN OUTCOME MEASURE(S):

Clinical pregnancy (CP), defined as evidence of intrauterine gestation sac on ultrasound, following IVF; IVF cycle parameters.

RESULT(S):

Serum and FF levels of 25OH-D were highly correlated (r=0.94). In a predominantly Caucasian population (66%), significantly lower FF 25OH-D levels were noted in Black versus non-Black patients. Significant inverse correlations were seen between FF 25OH-D levels and body mass index (r=-0.25). Significantly higher CP and implantation rates were observed across tertiles of FF25OH-D; patients achieving CP following IVF (n=26) exhibited significantly higher FF levels of 25OH-D. Multivariable logistic regression analysis confirmed FF 25OH-D levels as an independent predictor to success of an IVF cycle; adjusting for age, body mass index, ethnicity, and number of embryos transferred, each ng/mL increase in FF 25OH-D increased the likelihood for achieving CP by 6%.

CONCLUSION(S):

Our findings that women with higher vitamin D level in their serum and FF are significantly more likely to achieve CP following IVF-embryo transfer are novel. A potential for benefit of vitamin D supplementation on treatment success in infertile patients undergoing IVF is suggested and merits further investigation.

PMID:
19589516
PMCID:
PMC2888852
DOI:
10.1016/j.fertnstert.2009.05.019
[Indexed for MEDLINE]
Free PMC Article

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