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Biochim Biophys Acta. 2010 Feb;1803(2):174-82. doi: 10.1016/j.bbamcr.2009.06.002. Epub 2009 Jul 7.

Formin-binding proteins: modulators of formin-dependent actin polymerization.

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Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Box 280, Nobels väg 16, SE-171 77 Stockholm, Sweden.


Formins represent a major branch of actin nucleators along with the Arp2/3 complex, Spire and Cordon-bleu. Formin-mediated actin nucleation requires the formin homology 2 domain and, although the nucleation per se does not require additional factors, formin-binding proteins have been shown to be essential for the regulation of formin-dependent actin assembly in vivo. This regulation could be accomplished by formin-binding proteins being directly involved in formin-driven actin nucleation, by formin-binding proteins influencing the activated state of the formins, by linking formin-driven actin polymerization to Arp2/3 driven actin polymerization, or by influencing the subcellular localization of the formins. This review article will focus on mammalian formin-binding proteins and their roles during vital cellular processes, such as cell migration, cell division and intracellular trafficking.

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