Format

Send to

Choose Destination
See comment in PubMed Commons below
J Pharm Pharmacol. 2009 Jul;61(7):831-7. doi: 10.1211/jpp/61.07.0001.

Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research.

Author information

1
Department of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China.

Abstract

OBJECTIVES:

This review summarizes recent research on the neuropharmacological and pharmacokinetic properties of berberine, an isoquinoline alkaloid extracted from Coptidis rhizoma.

KEY FINDINGS:

Berberine has multiple neuropharmacological properties, such as neuroprection, anti-neuronal apoptosis, improvement of cerebral microcirculation and anti-Alzheimer's disease, and so on. The pharmacokinetic characteristics of berberine are that it is not easily absorbed and it is not stable in the gastrointestinal tract of animals or humans.

SUMMARY:

Further studies need to be carried out to develop berberine as a drug for nervous system diseases, such as brain ischaemia and Alzheimer's disease, that has favorable pharmacokinetic properties.

PMID:
19589224
DOI:
10.1211/jpp/61.07.0001
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center