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J Biol. 2009;8(6):58. doi: 10.1186/jbiol155. Epub 2009 Jun 16.

Oxidative stress, thermogenesis and evolution of uncoupling proteins.

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1
Centro de Investigaciones Biológicas, CSIC, Madrid, Spain. rial@cib.csic.es

Abstract

The uncoupling protein UCP1 provides eutherian mammals with an efficient thermogenic mechanism. Recent work published in BMC Evolutionary Biology, following the identification of UCP1 orthologs in non-eutherians, concludes that this unique function appeared after sequence divergence and purifying selection that allowed functional co-option.

PMID:
19589183
PMCID:
PMC2737370
DOI:
10.1186/jbiol155
[Indexed for MEDLINE]
Free PMC Article
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