Format

Send to

Choose Destination
Mucosal Immunol. 2009 Sep;2(5):403-11. doi: 10.1038/mi.2009.100. Epub 2009 Jul 8.

Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa.

Author information

1
Department of Pediatrics (Pulmonology) and Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Abstract

T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in autoimmunity is well documented, there is growing evidence that the Th17 lineage and other interleukin (IL)-17-producing cells are critical for host defense against bacterial, fungal, and viral infections at mucosal surfaces. Here we summarize recent progress in our understanding of the function of IL-17-producing cells as a bridge between innate and adaptive immunity against infectious diseases at the mucosa.

PMID:
19587639
PMCID:
PMC2811522
DOI:
10.1038/mi.2009.100
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center