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Ann Hematol. 1991 Nov;63(5):282-7.

Translocation (14; 18) and (8; 22) in three patients with acute leukemia/lymphoma following centrocytic/centroblastic non-Hodgkin's lymphoma.

Author information

1
Department of Oncology and Hematology, University Hospital Eppendorf, Hamburg, Federal Republic of Germany.

Abstract

Three patients with centrocytic/centroblastic lymphoma developed a rapidly fatal leukemic transformation of the disease after a transient remission. At the time of transformation, cytogenetic analysis revealed in all patients abnormal karyotypes with coexistence of t (14; 18) and t (8; 22). Molecular analysis in one patient showed rearrangement of the BCL 2 oncogene and c-myc m-RNA expression. These findings imply that translocation t (14; 18) was present during the first phase of the disease and that acquisition of translocation t (8; 22) was accompanied by leukemic transformation.

PMID:
1958753
DOI:
10.1007/bf01698379
[Indexed for MEDLINE]

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