Format

Send to

Choose Destination
Biosci Biotechnol Biochem. 2009 Jul;73(7):1685-9. Epub 2009 Jul 7.

Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation.

Author information

1
Department of Immunology, College of Pharmacy, Research Institute for Translational System Biomics, Chung-Ang University, Seoul, Korea.

Abstract

Beta-amyloid (Abeta) has been suggested to induce neurotoxicity in Alzheimer's disease. We evaluated the neuroprotective effects of delphinidin, an anthocyanidin commonly present in pigmented fruits and vegetables, against Abeta-induced toxicity. Abeta (25-35) significantly decreased the viability of PC12 cells, and this was accompanied by an increase in intracellular calcium levels and tau phosphorylation. However, treatment with delphinidin rescued PC12 cells from Abeta by attenuating the elevation of intracellular calcium levels and tau phosphorylation. Taken together, these results suggest that delphinidin protects PC12 cells against Abeta-induced toxicity by attenuating intracellular calcium influx and tau hyperphosphorylation.

PMID:
19584523
DOI:
10.1271/bbb.90032
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center