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Cancer Prev Res (Phila). 2009 Jul;2(7):634-40. doi: 10.1158/1940-6207.CAPR-09-0052.

Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs.

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1
Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Antitumor B (ATB) is a Chinese herbal mixture of six plants. Previous studies have shown significant chemopreventive efficacy of ATB against human esophageal and lung cancers. We have recently developed a new mouse model for lung squamous cell carcinomas (SCC). In this study, lung SCC mouse model was characterized using small-animal imaging techniques (magnetic resonance imaging and computed tomography). ATB decreased lung SCC significantly (3.1-fold; P < 0.05) and increased lung hyperplastic lesions by 2.4-fold (P < 0.05). This observation suggests that ATB can block hyperplasia from progression to SCC. ATB tissue distribution was determined using matrine as a marker chemical. We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs.

PMID:
19584077
PMCID:
PMC3890236
DOI:
10.1158/1940-6207.CAPR-09-0052
[Indexed for MEDLINE]
Free PMC Article
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