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Cell Metab. 2009 Jul;10(1):7-8. doi: 10.1016/j.cmet.2009.06.004.

The gutsy side of bone.

Author information

1
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Abstract

Though surgical removal of the stomach has long been linked to low bone mass, the molecular mechanism has been elusive. Amling and coworkers now demonstrate that gastric cell acid production is necessary for calcium absorption. Mice lacking this acidification develop hypocalcemia, with increased parathyroid hormone and osteoclast differentiation, and decreased bone mass.

PMID:
19583948
DOI:
10.1016/j.cmet.2009.06.004
[Indexed for MEDLINE]
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