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Cell Metab. 2009 Jul;10(1):1-2. doi: 10.1016/j.cmet.2009.06.005.

Beta testing the antioxidant function of eIF2alpha phosphorylation in diabetes prevention.

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1
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. rwek@iupui.edu

Abstract

In this issue of Cell Metabolism, Kaufman and colleagues (Back et al., 2009) elegantly demonstrate that appropriate regulation of eIF2alpha phosphorylation improves glucose tolerance and beta cell viability by preventing the lethal buildup of oxidative damage due to unregulated synthesis, trafficking, and misfolding of proteins.

PMID:
19583945
DOI:
10.1016/j.cmet.2009.06.005
[Indexed for MEDLINE]
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