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Immunol Today. 1991 Oct;12(10):370-4.

Modulation of T-cell function by gliomas.

Author information

1
Dept of Microbiology and Immunology, University of Kentucky Medical Center, Lexington 40536.

Abstract

Patients with primary intracranial tumors (gliomas) exhibit a profound decrease in immunity, the mechanism of which has, until recently, remained obscure. Here Thomas Roszman, Lucinda Elliott and William Brooks reveal that T cells obtained from these patients exhibit defects in interleukin 2 secretion and in expression of the high-affinity IL-2 receptor and they discuss the role played by immunosuppressive factors produced by gliomas in inducing these defects.

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PMID:
1958290
DOI:
10.1016/0167-5699(91)90068-5
[Indexed for MEDLINE]

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