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Biochem Biophys Res Commun. 1991 Nov 27;181(1):265-71.

Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture.

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Department of Neurology, Faculty of Medicine, Kyoto University, Japan.


We investigated the effect of human beta-amyloid precursor protein (APP) on rat primary cerebral cortical neurons cultured in a serum-free medium. Two secretory APP species (APP667 and APP592) with and without the protease inhibitor domain were produced by COS-1 cells transfected with APP cDNAs, which encode the N-terminal portions of APP770 and APP695. Both highly purified APP species, when added to the medium, enhanced neuronal survival and neurite extension in a dose-dependent manner with a maximum effect at approximately 100 nM. These results suggest that secreted forms of APP have trophic activity for cerebral cortical neurons.

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