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Biophys J. 2009 Jul 8;97(1):83-9. doi: 10.1016/j.bpj.2009.04.040.

Structural and viscoelastic properties of actin/filamin networks: cross-linked versus bundled networks.

Author information

1
Lehrstuhl für Zellbiophysik E27, Technische Universität München, Garching, Germany.

Abstract

The high diversity of cytoskeletal actin structures is accomplished by myriads of actin binding proteins (ABPs). Depending on its concentration, even a single type of ABP can induce different actin microstructures. Thus, for an overall understanding of the cytoskeleton, a detailed characterization of the cross-linker's effect on structural and mechanical properties of actin networks is required for each ABP. Using confocal microscopy and macrorheology, we investigate both cross-linked and bundled actin/filamin networks and compare their microstructures as well as their viscoelastic properties in the linear and the nonlinear regime.

PMID:
19580746
PMCID:
PMC2711384
DOI:
10.1016/j.bpj.2009.04.040
[Indexed for MEDLINE]
Free PMC Article

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